Mycophenolic Acid Production by Drug-resistant and Methionine or Glutamic-Acid Requiring Mutants ofPénicillium brevicompactum
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چکیده
منابع مشابه
Enhanced Mycophenolic Acid Production by Penicillium brevicompactum with Enzymatically Hydrolyzed Casein
Mycophenolic acid (MPA) is a secondary metabolite produced by Penicillium brevicompactum, which has antibiotic and immunosuppressive properties. In this study, the first, mycophenolic acid was produced in a fermentation process by Penicillium brevicompactum MUCL 19011 in shake flask using a base medium. The maximum MPA production, product yield and productivity of process were 1.379 g/L, 18.6 m...
متن کاملProduction of mycophenolic acid by Penicillium brevicompactum—A comparison of two methods of optimization
Production of mycophenolic acid (MPA) by submerged fermentation using the microfungus Penicillium brevicompactum MTCC 8010 is reported here. Screening experiments were used to identify: the suitable media composition; the optimal initial pH; and the optimal incubation temperature to maximize the production of MPA in batch cultures. The initial concentrations of the selected sources of carbon (g...
متن کاملMolecular basis for mycophenolic acid biosynthesis in Penicillium brevicompactum.
Mycophenolic acid (MPA) is the active ingredient in the increasingly important immunosuppressive pharmaceuticals CellCept (Roche) and Myfortic (Novartis). Despite the long history of MPA, the molecular basis for its biosynthesis has remained enigmatic. Here we report the discovery of a polyketide synthase (PKS), MpaC, which we successfully characterized and identified as responsible for MPA pro...
متن کاملEffects of Phenylglyoxal and N-ethylmaleimide Concentration on Mycophenolic Acid Production by Penicillium brevi-compactum ATCC16024
Mycophenolic acid is a secondary extracellular metabolite of Penicillium strains with numerous pharmaceutical properties such as antibiotic and immunosuppressive uses. The aim of this work is the survey of the effect of phenylglyoxal and n-ethylmaleimide concentration in culture medium on mycophenolic acid production by Penicillium brevi-compactum ATCC16024 was investigated. Batch submerged fer...
متن کاملL-isoleucine Effects on Yield and Productivity of a Batch Fermentation Process for Mycophenolic Acid Production by Penicillium brevicompactum
Mycophenolic acid (MPA) is an antibiotic and immunosuppressive agent has been produced as a secondary metabolite of some fungi species such as Penicillium. In the present work, in the first step, mycophenolic acid production was performed in a fermentation process by Penicillium brevicompactum MUCL 19011 in shake flask using a base medium. Obtained results demonstrated the maximum MPA productio...
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ژورنال
عنوان ژورنال: Agricultural and Biological Chemistry
سال: 1987
ISSN: 0002-1369
DOI: 10.1080/00021369.1987.10868427